Going out to detect incipient diabetic nephropathy rather than waiting until it has supervened—a reversal in policy

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Going out to detect incipient diabetic nephropathy rather than waiting until it has supervened--a reversal in policy.

Persistent albuminuria (>300 mg/24 h or 200 ug/min) is the hallmark of diabetic nephropathy, which can be diagnosed clinically if the following additional criteria are fulfilled: presence of diabetic retinopathy and no clinical or laboratory evidence of kidney or urinary tract disease other than diabetic glomerulosclerosis [1]. This clinical definition of diabetic nephropathy is valid both in i...

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Progression of Incipient Diabetic Nephropathy

The aim of the study was to clarify whether antihypertensive treatment with a selective beta blocker would have an effect on the progression rate of kidney disease in patients with incipient diabetic nephropathy. Six male patients with juvenile-onset diabetes with incipient nephropathy (urinary albumin excretion above 15 /ig/min and total protein excretion below 0.5 g/24 hr) were treated with m...

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Urinary Exosomal MicroRNAs in Incipient Diabetic Nephropathy

MicroRNAs (miRNAs), a class of small non-protein-encoding RNAs, regulate gene expression via suppression of target mRNAs. MiRNAs are present in body fluids in a remarkable stable form as packaged in microvesicles of endocytic origin, named exosomes. In the present study, we have assessed miRNA expression in urinary exosomes from type 1 diabetic patients with and without incipient diabetic nephr...

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Incidence and Determinants of Incipient Diabetic Nephropathy

Diabetic nephropathy is a late complication of diabetes mellitus. Microalbuminuria is considered to be an early sign of diabetic renal disease. It precedes persistent proteinuria and represents a potentially reversible stage of diabetic nephropathy. This cross-sectional analytical study was carried out on 180 type 2 and 145 type 1 diabetic patients. Patients having clinical albuminuria and with...

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ژورنال

عنوان ژورنال: Nephrology Dialysis Transplantation

سال: 1996

ISSN: 1460-2385,0931-0509

DOI: 10.1093/ndt/11.9.1728